Other than natural disasters, diseases are the most known
entities to cause mass death in the human population. Disease is an abnormal
condition that affects the body of an organism. It is often considered a
medical condition with each disease having its own specific symptoms and signs.
Diseases can be caused by many things such as external sources, other infected
people, or internal sources due to hereditary predispositions. There are four
main types of disease: pathogenic disease, deficiency disease, hereditary
disease, and physiological disease (Johnson 2002). A pathogen is an infectious
agent (germ) that can cause disease in a host body. The host can be any plant,
animal, human, or other microorganisms. Examples of pathogenic diseases are
smallpox, influenza, chickenpox, and measles. Deficiency disease (nutritional
disease) is a disease in humans that can be directly or indirectly caused by
missing essential nutrients in the everyday diet. This disease is known for
causing two extreme reactions, obesity and malnutrition. Hereditary disease is
a genetic disorder. It can be caused by mutations and abnormalities in the
genome. This disease is also characterized as a lifelong disease because it is
usually present in the child from birth. These diseases are also heritable and
can be passed down from generation to generation. An example of this disease is
certain forms of cancer. A physiological disease is what the normal regulation
of the body’s system is affected. This can result from certain organs in the
body not working properly or if certain cellular structures change over time,
it can cause illness. An example of a physiological disease is asthma or
diabetes.
The top ten deadliest epidemics
of all time are categorized by one of the four groups listed and has had
extremely negative consequences on the human population. The biggest worldwide
epidemic was smallpox. Smallpox is an extremely infectious pathogenic disease.
Smallpox was characterized by a rash and after fluid-filled blisters which can
cause blindness, scarring, limb deformities, and in many cases, death (Barquet
and Domingo 1997). Smallpox is believed to have first been found in the
mummified remains of Ramses V who died over 3000 years ago. Through trading
routes between Egypt and India, it is believed that the disease spread and from
there was introduced to China and then Japan. It is unclear how it began to
spread to the rest of the world, but by the time of the Middle Ages, the
population increased and around the 16th century smallpox was well established
throughout many regions in Europe. Smallpox continued to ravage the world and
by the mid-18th century it was a major endemic disease everywhere
but Australia. In Europe during the 18th century it was the leading
cause of death killing at least 400,000 people per year. Death was rampant
until the use of vaccinations. Through the push of the governments, and
donations of vaccines to poorer countries, smallpox was finally eradicated in 1979.
Smallpox was to blame for 300 to 500 million deaths during the 20th
century and at the height, about 15 million people contracted the disease per
year and about 2 million of them died. Overall, smallpox was definitely a
disease, during its height that affected the growth of the human population. It
put natural holds on growth until its eradication and then once again the
population began to grow (Barquet and Domingo 1997).
The second largest epidemic of
all time was the measles. The measles is also a pathogenic disease which
infects the respiratory system. Symptoms of the measles include fever, cough,
running nose, red eyes, and rashes. Measles are also highly contagious and can
by caught through transmission of respiratory fluids (Broy et al 2009). While
the measles today are rarely fatal, it was not the same case throughout
history. The first known case of the measles was known as the Plague of Galen
around 165-180 AD. It killed one third of the population in certain areas and
is the cause for extreme loss in the Roman army. In 1529, an outbreak of the
disease in Cuba killed two-thirds of the native people there after they already
survived a smallpox outbreak. From there it continued to ravage Honduras,
Mexico, Central America, and the Incas. In the last 150 years alone, measles
has been thought to have killed about 200 million people around the world. It
has been extremely hard to eradicate measles completely because to date, 21
strains exist and can at any time produce more strains. While vaccines have definitely
improved the mortality rate of those who contract measles, there are still
outbreaks today. One of the most recent large outbreaks happened in Japan in
2007, in Bulgaria in 2009, and as recent as March of 2013 with over 1000 cases
and one death. While death is not common last stage for the measles anymore, it
still can produce some fatalities. There is no denying that measles definitely
affected population growth (Broy et al 2009).
The third largest epidemic was
the Black Death. While it does not have any recent cases in the past couple
centuries, the centuries that it was present, were devastating. The Black Death
is a pathogen from bacteria that caused several forms of the plague. Symptoms
of the disease were pustules formed in the groin, neck, and armpits which oozed
pus and bled when opened. Other signs included spots, rashes, fever, and
vomiting, but most of the time, death was certain from two to seven days after
contraction. The Black Death had origins either in or nearby China. It spread to
other parts of the world either through the Silk Road trade route or by ships
(Herlihy 1997). There have been three major outbreaks of the plague. The first
was the Plague of Justinian around the 6th and the 7th
centuries. This outbreak is the first known attack of the Black Death as well
as the first patterns of the bubonic plague. During this outbreak, almost forty
percent of the population of Constantinople died from the plague. The plague
continued till it wiped out about half of Europe’s population and then
declined. The plague was not seen again in Europe until the Black Death in the
14th century. Here the plague reached its peak. It had a drastic
affect on the European population, decimating huge numbers of people. The
plague had caused rampant death, despair, and persecution of minorities as
scapegoats for the introduction of the plague into society. In the 14th
century alone, it is estimated that the Black Death reduced the world
population from 450 million to 350 million. The third pandemic hit China around
the late 1800’s and also affected India, but the plague stayed within the
confines of the West. Since the last outbreak, there has only been limited
number of cases in the past century. Overall the plague has killed over 100
million people within a small time period and is one of the more violent
epidemics which have affected the world population (Herlihy 1997).
While all of the top ten
epidemics have caused countless of deaths on the world population throughout
history, there are a handful that still cause death today. In addition to small
outbreaks of the measles, malaria, tuberculosis, and AIDS still wreak havoc in
society today. Malaria is a mosquito borne infectious disease. It begins with a
bite from a mosquito and the saliva of the infected insect travels through your
blood. Malaria causes symptoms that typically include fever, headache, and can
progress to a coma or death. The disease is widespread in certain tropical
regions including many areas around the equator because the conditions prove to
be a perfect breeding habitat for mosquitoes. In 2010 alone, there had been an
estimated 219 million documented cases and around 1.2 million deaths from the
disease. In total, there is an upwards of 80 million deaths from malaria.
Currently there are no effective vaccines that exist for malaria although there
is research being conducted to create one. There are other defenses against
malaria such as antimalarial drugs, but countries without access to these drugs
and with no vaccinations, malaria will continue to be a deadly epidemic (Sarkar
et al 2009). Tuberculosis is a common and lethal infectious disease caused by
different strains of the bacteria, Mycobacterium
tuberculosis. Tuberculosis is characterized by attacking mainly the lungs
and can also spread to other parts of the body. It can spread through the air and
be transmitted from person to person. The symptoms of tuberculosis are
coughing, fever, night sweats, and weight loss. It is believed that about one
third of the world’s population was infected with tuberculosis with new
infections happening at a rate of about one per second. Every year there are
millions of cases of tuberculosis. In 2010, 8.8 million cases were reported and
about 1.5 million deaths as a result either directly or indirectly from
tuberculosis. Currently, under developed countries still have many cases of
tuberculosis because of compromised and weak immune systems after contracting
HIV and AIDS. There have been between 40 to 100 million deaths from
tuberculosis (Lawn and Zumla 2011). The last of the major epidemics currently
in existence is AIDS. AIDS is a disease
of the human immune systems caused by an infection of human immunodeficiency virus
(HIV). With the initial contraction of HIV, there are influenza-like symptoms. After,
there can be long periods without any symptoms at all while the virus slowly
attacks the immune system. The last
stage of HIV is considered to be AIDS. HIV is transmitted through unprotected
sexual intercourse and exchange of bodily fluids. Because HIV/AIDS attacks the
immune system, a person is much more likely to be affected by other diseases
and sicknesses because the body cannot fight against it. Since the discovery of
AIDS, it has caused about 30 millions deaths as of 2009 and as of 2010, it is
estimated that 34 million people are living with it around the world. There are
no cures or vaccines as of now, but there are ways to slow the course of the disease
(Baggaley et al 2006).
Figure 5: Table of the top ten deadliest epidemics
Disease, in the past and in the present, has affected populations.
Disease alone is responsible for killing over a billion people in the world. It
has wreaked havoc on population in the history through means such as small pox
or the Black Death, and currently affects our population through AIDS, malaria,
and tuberculosis. It is hard to infer if these diseases will become worse with
time, or if new diseases will be formed, but disease is definitely a huge
factor affecting the world population.